USP 7 ( ubiquitin specific peptidase 7 ( herpes virus - associated ) )
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منابع مشابه
Cleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells.
The human cytomegalovirus (HCMV) open reading frame UL48 encodes a 253-kDa tegument protein that is closely associated with the capsid and was recently shown to have ubiquitin-specific protease activity (J. Wang, A. N. Loveland, L. M. Kattenhorn, H. L. Ploegh, and W. Gibson, J. Virol. 80:6003-6012, 2006). Here, we examined the cleavage specificity of this deubiquitinase (DUB) and replication ch...
متن کاملA herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.
The herpesvirus ubiquitin-specific protease (USP) family, whose founding member was discovered as a protease domain embedded in the large tegument protein of herpes simplex virus 1 (HSV-1), is conserved across all members of the Herpesviridae. Whether this conservation is indicative of an essential function of the enzyme in vivo has not yet been established. As reported here, USP activity is co...
متن کاملRESEARCH COMMUNICATION No Association Between the USP7 Gene Polymorphisms and Colorectal Cancer in the Chinese Han Population
Ubiquitin specific protease 7 (USP7), also known as herpes virus-associated ubiquitin specific protease (HAUSP), belongs to the ubiquitin specific peptidase class of deubiquitination enzymes (Everett et al., 1997; Hu et al., 2002). It plays an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression (Li et al., 2002). p53, one of the most impor...
متن کاملActivity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.
The family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a variety of cellular processes. The human genome contains many putative USP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity, and substrate specificity. We have used a chemistry-based functional proteomics approach to identify active USPs in normal...
متن کاملOncogenic viruses: DUBbing their way to cancer
Ubiquitination is one of the most important post-translational modifications of proteins with a profound effect on their intracellular stability and activity. Deubiquitinases (DUBs), on the other hand, act by removing the ubiquitin moiety from proteins and thereby reverse their stability and/or activity. Besides, DUBs play a major role in maintenance of free ubiquitin pool, histone modification...
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تاریخ انتشار 2011